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Welcome to BioCity
News & Events
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Cancer Biomarkers - New Methods of Discovery
17th January 2012, 5pm-7pm at BioCity Nottingham
Scientists have been searching for cancer biomarkers for many years, but the methods of discovery have changed as new technologies have been developed.
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Professor Graham Ball PhD BSc (hons)FSB NottinghamTrent University/ CompanDX Ltd
Title: Development of prognostics models form clinical
population models to genomic personalised predictions. Cancer is a complex disease with a myriad of forms and
prognoses occurring within each type. For example in breast cancer using genomic profiling in excess of 80 sub
types have been identified. The ability
to characterise the disease for each patient may offer the potential to assess
the molecular sub-type of the disease and thus accurately determine the
patients’ prognostic outcome. Methodologies
such as mass spectrometry based proteomics and gene expression arrays offer the
potential for characterisation of disease derived samples using a huge number
of proteins or genes. This depth of
information while providing a comprehensive overview of a disease state also
proves problematic in its complexity. One has to search through potentially hundreds of thousands of pieces of
information for consistent features that address a clinical question in the
population.
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Andrew McEwen, PhD, Chief Scientist,
Department of Metabolism
Quotient Bioresearch
Title: MALDI – The Alternative to QWBA
Imaging mass spectrometry offers the promise of direct examination of molecules, metabolites and biomarkers in cells and tissues. Using MALDI thespatial distribution information can be obtained which makes it potentially anideal tool for diagnostic and molecular histology studies. This presentation will provide an overview of the technology involved from sample preparation toimage generation and discuss whether the MALDI technique will be provide newinsights in to molecular processes in living tissue.
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